Yes it runs on OS X.
The minimal recommended requirement is...
=> Mac: Lion ( 10.7 ), Mountain Lion ( 10.8 ), Maverick ( 10.9 ), Yosemite ( 10.10 ), El Capitan ( 10.11 ) & Sierra ( 10.12 ) <=
Windows: Vista, 7, 8 & 10
Linux : Ubuntu 12.04+, Debian 6+, RedHat Entreprise Linux 5+, Fedora 15+
Processor : any dual-core processor
RAM : 2GB
Free hard drive space : 10GB
Architecture : 32 and 64 bit (Standard Edition runs in 32 bit only, but is compatible on 64 bit OS)
The performance of TVPaint Animation is only dependent on speed and amount of available RAM, hard drive speeds, and number and speed of processor cores.
There is no need to invest in an expensive video card to make full use of TVPaint Animation.
https://www.tvpaint.com/
Question about tvpaint mac Topic is solved
Re: Question about tvpaint mac
Main System: Mac Mini running OS X: Big Sur | M1 | 16GB RAM | have not installed TVPaint on new M1 need to update to current as of 9/2022 ...pending non-dongle license 1/2023 | iPad Pro, Apple Pencil and Astropad | Wacom Intros Pro