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I made the mistake of outputting a final project in H.264 once, as I really love the codec, but that came back to bite me eventually. I have since stuck with the Apple Intermediate Codec, which is "visually lossless" according to them. The file sizes are large, but nowhere near uncompressed large. I haven't had to deal with the artifact and color issues of H.264 since. I still swaer by H.264 for my site and anything that appears on it though.

artfx wrote:Apple Intermediate Codec

Interesting. I hadn't heard of that one before and it doesn't appear on my system (PC). I do have the 'Animation' flavour which at best quality is supposed to be lossless. I've always used that to good effect in the past
Shame apple has stopped PC development of QT as what we all need is a free, lossless cross platform codec so we can spend more time creating