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with the current architecture, is it possible to add layer 'blending' options (like After Effects and Photoshop has) without the need to set up the keyframer and apply?
something like a pulldown menu in the layers panel, or an addition to the pop-up menu, that will let us change from Normal to Multiply to Add etc. (maybe even Alpha only mode?)

I know this sounds like I want more compositing features (which is unlike me) but I use bleding modes to experiment with visuals and looks, and I just hate reverting to After Effects for stuff like that. I love to do everything in tvpaint, and from there straight to the editor for some sound.

The blending modes is something that is requested for a long time.
It's always good to us that people keep requesting things like that, that will only make us do them.
That's the case with the blending modes... but i can't say when for the moment.